Billy Cannon of Louisiana State University gained 598 yards rushing, an average of ran them back for 221 yards, returned eight kickoffs for 191 yards, scored seven touchdowns and punted 44 times for an average of 40.3 yards. The shifty, slashing 6'1", 210-pound "atomic cannon" was clocked in the hundred in 9.4 and was the scourge of LSU's Southeastern Conference opponents for three years. Cannon went on to a distinguished career in pro ball with the Houston Oilers (4 years), the Oakland Raiders (6 years) and the Kansas City Chiefs (1 year). He was named All-Pro halfback with Houston and All-Pro tight end with Oakland. During his pro years Billy went to dental school at the University of Tennessee, graduating in 1968 with a D.D.S. He continued a graduate program in orthodontia at Loyola in Chicago, gaining two additional degrees. Billy and his wife Dorothy have five children and reside in Baton Rouge , LA, where he is an orthodontist.
| | Points | |||||||
Place | Name | School | Class | Position | 1 | 2 | 3 | Total |
| 1 | Billy Cannon | Louisiana State | Sr. | HB | 519 | 147 | 78 | 1,929 |
| 2 | Richie Lucas | Penn State | Sr. | QB | 97 | 109 | 104 | 613 |
| 3 | Don Meredith | Southern Methodist | Sr. | QB | 26 | 67 | 74 | 286 |
| 4 | Bill Burrell | Illinois | Sr. | G-LB | 23 | 47 | 33 | 196 |
| 5 | Charlie Flowers | Mississippi | Sr. | FB | 11 | 58 | 44 | 193 |
| 6 | Dean Look | Michigan State | Sr. | HB | 23 | 41 | 25 | 176 |
| 7 | Dale Hackbart | Wisconsin | Sr. | QB | 19 | 21 | 35 | 134 |
| 8 | Dwight Nichols | Iowa State | Sr. | RB | 21 | 25 | 13 | 126 |
| 9 | Monte Stickles | Notre Dame | Sr. | E | 16 | 21 | 36 | 126 |
| 10 | Ron Burton | Northwestern | Sr. | RB | 10 | 28 | 36 | 122 |
LSU star Billy Cannon was a runaway winner, with his 1,316-point margin over Richie Lucas of Penn State ranking was the ninth highest in Heisman history. Cannon finished first in all five sections and had 519 first place votes to only 97 for runner-up Lucas.
Number of registered electors: 1,197
Date of announcement: December 1, 1959
Date of dinner: December 9, 1959
The positions within each region:
Place | East | South | Midwest | Southwest | Far West |
| 1 | Cannon | Cannon | Cannon | Cannon | Cannon |
| 2 | Lucas | Flowers | Lucas | Meredith | Schloredt |
| 3 | Davis | Luicas | Burrell | Lucas | Lucas |
| 4 | Stickles | Meredith | Look | Flowers | Meredith |
| 5 | Schwedes | Davis | Hackbart | Stickles | Look |